One of the best receivers in the league will be on display when George Kittle and the San Francisco 49ers visit the Buffalo Bills on Sunday, December 1, 2024.
With 23.6 points per game on offense, the 49ers rank 13th in the NFL. Defensively, they rank 20th, surrendering 23.6 points per contest. Offensively, the Bills rank 13th in the NFL with 345.3 yards per game. Meanwhile, they rank 15th in total defense (329.1 yards allowed per contest).
49ers vs Bills: live streaming info, TV channel & game time
49ers vs Bills betting lines
NFL odds courtesy of BetMGM. Odds updated Sunday at 12:45 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: Bills (-6)
Moneyline: Bills (-278), 49ers (+226)
Total: 44.5 points
Watch Bills vs. 49ers on Fubo!
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