Star pass-catcher George Kittle and the San Francisco 49ers meet the Buffalo Bills on Sunday at 8:20 p.m. ET at Highmark Stadium.
The Bills sport the seventh-ranked defense this season (19.5 points allowed per game), and they’ve been more effective on the other side of the ball, ranking third-best with 29.1 points per game. From an offensive standpoint, the 49ers are putting up 23.6 points per contest (13th-ranked). They rank 20th in the NFL on the other side of the ball (23.6 points surrendered per game).
Bills vs 49ers: live streaming info, TV channel & game time
Bills vs 49ers betting lines
NFL odds courtesy of BetMGM. Odds updated Saturday at 8:21 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: Bills (-6)
Moneyline: Bills (-277), 49ers (+226)
Total: 44.5 points
Watch Bills vs. 49ers on Fubo!
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