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The Detroit Lions and San Francisco 49ers play on Monday, Dec. 30 at the 49ers’ Levi’s Stadium in a game on the NFL Week 17 schedule.
Which team will win the Monday Night Football game?
Check out these NFL Week 17 picks and NFL Week 17 predictions for the game, which can be seen at 6:15 p.m. MST on ABC and ESPN (stream with FUBO).
The Lions are a 3.5-point favorite over the 49ers in NFL Week 17 odds for the game, courtesy of BetMGM Sportsbook.
Detroit is -190 on the moneyline, while San Francisco is +155.
The over/under (point total) is set at 51.5 points.
NFL Week 17 picks: Chiefs vs Steelers | Ravens vs Texans | Seahawks vs Bears | Chargers vs Patriots | Broncos vs Bengals | Cardinals vs Rams | Colts vs Giants | Jets vs Bills | Titans vs Jaguars | Cowboys vs Eagles | Raiders vs Saints | Panthers vs Buccaneers | Dolphins vs Browns | Packers vs Vikings | Falcons vs Commanders | Lions vs 49ers | The Arizona Republic’s predictions
Watch Lions at 49ers on FUBO (free trial)
Jeremy Cluff writes: “Every NFL team has injuries, but both of these teams seem to have more than their fair share. The Lions have been able to deal with them better, however, and we don’t expect that to change this week.”
The site’s formula predicts that the Lions will win the NFL Week 17 game against the 49ers.
ESPN: Lions have a 62.5% chance to beat 49ers on Monday Night Football
The site gives the 49ers a 37.2% shot at winning the NFL Week 17 game, with the remaining percentage accounting for a tie.
Dimers: 49ers 26, Lions 23
It writes: “After extensive simulations, our model gives the Lions a win probability of 36%, while the 49ers have a win probability of 64%.”
Matt Johnson writes: “While the Detroit Lions are banged-up, the NFL schedule worked out nicely for them with some winnable games versus bad teams in December. The San Francisco 49ers haven’t been able to stop the run all season and Kyle Shanahan’s offense is one-dimensional because of all the injuries at running back. San Francisco will have some explosive plays against the Lions defense, but Detroit should be in control of this one for all four quarters.”
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Reach Jeremy Cluff at [email protected]. Follow him on X, formerly Twitter @Jeremy_Cluff.
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