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San Francisco Giants at Cincinnati Reds odds, picks and predictions

March 27, 2025
in Sport
San Francisco Giants at Cincinnati Reds odds, picks and predictions
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The Cincinnati Reds host the San Francisco Giants Thursday in the opener of a 3-game series Thursday. First pitch from Great American Ball Park to help commence Opening Day is set for 4:10 p.m. ET. Let’s analyze BetMGM Sportsbook’s MLB odds around the Giants vs. Reds odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting; Giants won 4-2 in 2024

The Reds didn’t have a strong spring, going 12-17, which included a 7-game losing streak. They are coming off a fourth-place finish in the NL Central, ending last season with a 77-85 record. Cincinnati was 39-42 at home. SS Elly De La Cruz, one of baseball’s most exciting players, is the Reds’ main star. They finished last season with the league’s best against the spread (ATS) record of 90-72.

The Giants also missed the playoffs a season ago, ending with an 80-82 record and finishing in fourth in the NL West. They went 38-43 on the road. San Francisco ended its spring training campaign on a high note, winning 4 of its last 5 games and 8 of its last 10. The Giants were 78-84 ATS a season ago. ESPN has the Giants 22nd in their preseason power rankings, just behind the Reds, who are 21st.

Giants at Reds projected starters

RHP Logan Webb vs. RHP Hunter Greene

Webb was 13-10 with a 3.47 ERA in 33 starts last season. He had a 1.23 WHIP, 2.2 BB/9 and 7.6 K/9 through an NL-high 204 2/3 innings.

Was first-time All-Star last season
Career vs. Reds: 2-2, 1.64 ERA (33 IP, 6 ER), 0.97 WHIP, 8.2 K/9 in 5 starts and 1 relief appearance
2024 vs. Reds: 1 start, loss, 7 IP, 2 ER, 8 H, 2 BB, 6 K in 4-2 home setback May 10
2024 road splits: 6-5, 4.11 ERA (103 IP, 47 ER), 1.43 WHIP, 8.1 K/9 in 18 starts

Greene was 9-5 with a 2.75 ERA last season with a 1.02 WHIP, 3.4 BB/9 and 10.1 K/9 through 150 1/3 innings in 26 starts.

Was first-time All-Star last season
Career vs. Giants: 2-0, 0.00 ERA (11 1/3 IP, 0 ER), 0.53 WHIP, 13.5 K/9 in 2 starts
2024 vs. Giants: 1 start, win, 6 IP, 0 ER, 1 H, 1 BB, 11 K in 6-4 home victory Aug. 3
2024 home splits: 5-4, 3.38 ERA (80 IP, 30 ER), 1.10 WHIP, 10.9 K/9 in 14 starts

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Giants at Reds odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of MLB odds. Lines last updated at 4:16 a.m. ET.

Moneyline (ML): Giants -110 (bet $110 to win $100) | Reds -110 (bet $110 to win $100)
Run line (RL)/Against the spread (ATS): Giants -1.5 (+145) | Reds +1.5 (-175)
Over/Under (O/U): 8 (O: -120 | U: +100)

Giants at Reds picks and predictions

Prediction

Reds 4, Giants 3

Moneyline

BET REDS (-110).

Greene has seen success against San Francisco, and Cincinnati will have a strong home crowd for the opener, which the city treats like a holiday. With De La Cruz and a slew of solid batters around him, the offense should be improved over last year as well.

The Giants are expected to be on a similar plane, but the Reds have the advantage of being at home. Webb hasn’t had great success over the years in Cincinnati, and San Francisco finished 38-42 on the road last season.

Take REDS (-110).

Run line/Against the spread

PASS.

There’s no playable wager on the spread. Cincinnati is too expensive as an underdog, and San Francisco hasn’t improved its offense enough to be this strong of a favorite. AVOID a moneyline play.

Over/Under

BET UNDER 8 (-120).

The aces are on the mound, and that should help the total here. The Reds were one of the worst Over-hitting teams a season ago, finishing with a 73-81-8 O/U record.

The Giants went Under this total in 5 of their last 8 contests to end spring training. Considering the pitching strengths for both sides and recent trends, back UNDER 8 (-120).

If you don’t like risking the extra juice, FanDuel Sportsbook is offering Under 7.5 (+100).

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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