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The San Francisco 49ers and Buffalo Bills play Sunday, Dec. 1, at Buffalo’s Highmark Stadium in a game on the NFL Week 13 schedule.
Which team will win the Sunday Night Football game?
Check out these NFL Week 13 picks and NFL Week 13 predictions for the game, which can be seen at 6:20 p.m. MST on NBC (stream with Peacock).
The Bills are a 7-point favorite over the 49ers in NFL Week 13 odds for the game, courtesy of BetMGM Sportsbook.
Buffalo is -300 on the moneyline, while San Francisco is +240.
The over/under (point total) is set at 45.5 points.
NFL Week 13 picks: Bears vs Lions | Giants vs Cowboys | Dolphins vs Packers | Raiders vs Chiefs | Chargers vs Falcons | Steelers vs Bengals | Texans vs Jaguars | Cardinals vs Vikings | Colts vs Patriots | Seahawks vs Jets | Titans vs Commanders | Buccaneers vs Panthers | Rams vs Saints | Eagles vs Ravens | 49ers vs Bills | Browns vs Broncos | The Arizona Republic’s predictions
Watch 49ers at Bills live with Peacock
Jeremy Cluff writes: “At one point, we thought this game might end up being a Super Bowl preview, but the 49ers are not holding up their end this season. The struggles will continue for San Francisco against Josh Allen and the Bills in Buffalo.”
Bookies.com: Bet the Bills to cover vs 49ers
Bill Speros writes: “The 49ers have been flirting with disaster in true ‘Molly Hatchet’ form all season. This year’s version of the 49ers offers further proof that losing the Super Bowl takes at least a full season from which to recover. An injury-decimated version of the 49ers turned the ball over 3 times and was curb-stomped by Josh Jacobs and the Packers 38-10 Sunday at Green Bay. SF was without QB Brock Purdy, tackle Trent Williams, and Nick Bosa. Purdy is expected back this week. Still, the 49ers are 5-6 SU and 4-7 ATS. Yikes. Josh Allen may have clinched MVP honors with his game-winning dash against the Chiefs. Buffalo will follow Green Bay’s blueprint and keep the ball moving and on the ground. The Bills are making what will be a last run for the Super Bowl with this bunch. We locked this one at 3 points on the early line. It spiked to 6.5 Sunday night. Still, the Bills (9-2, 7-4 ATS) have covered in 5 of 6 games.”
The site’s formula predicts that the Bills will win the NFL Week 13 game against the 49ers.
NFL Week 13 odds: Who is favored in each game? | Super Bowl odds | NFL MVP odds | NFL Coach of the Year odds | NFC West odds | NFC East odds | NFC North odds | NFC South odds | AFC West odds | AFC East odds | AFC North odds | AFC South odds
ESPN: Bills have a 60.6% chance to beat 49ers on Sunday Night Football
The site gives the 49ers a 39.1% shot at winning the NFL Week 13 game, with the remaining percentage accounting for a tie.
Dimers: 49ers 24, Bills 22
It writes: “After extensive simulations, our model gives the 49ers a win probability of 57%, while the Bills have a win probability of 43%.”
NFL strength of schedule: NFC rankings | AFC rankings
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Reach Jeremy Cluff at [email protected]. Follow him on X, formerly Twitter @Jeremy_Cluff.
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