The first-place Buffalo Bills are on a six-game winning streak and getting healthier. The last-place San Francisco 49ers have dropped two straight games and are beleaguered by injuries.
Buffalo has Super Bowl aspirations and San Francisco played in the Super Bowl last year but is fighting for its playoff life.
The Bills (9-2) host the 49ers (5-6) at 8:20 p.m. on Sunday Night Football.
Buffalo is coming off a bye week, which has benefited several players on the mend. Wide receiver Keon Coleman, tight end Dalton Kincaid and offensive tackle Spencer Brown all missed the Bills’ 30-21 victory over the defending champion Kansas City Chiefs on Nov. 17. Linebacker Matt Milano has eased into practice since his 21-day window on injured reserve was opened by the Bills on Nov. 11. Defensive tackle DeWayne Carter is eligible to return off injured reserve.
San Francisco played without four key players – quarterback Brock Purdy, left tackle Trent Williams, defensive end Nick Bosa and cornerback Charvarius Ward – and was clobbered 38-10 by the Green Bay Packers on Sunday.
Purdy is nursing a shoulder injury and if he can’t go, Brandon Allen will start again for the 49ers. Allen is 2-8 in his career as a starter.
The 49ers expected to have Purdy under center against the Packers but he wasn’t able to practice on the Friday before the game. Purdy did light throwing on Monday but it’s unknown if he’ll be able to play against the Bills.
“Hopefully (the shoulder) responds better this week than it did last week with the rest,” San Francisco coach Kyle Shanahan said in his Monday conference call.
San Francisco plans to open the 21-day practice window for linebacker Drew Greenlaw, Shanahan said. Offensive guard Jon Feliciano will remain on injured reserve for the rest of the year.
NFL teams have to submit a report on practice participation on Wednesday, Thursday and Friday for a Sunday game. There are three levels of practice participation that can be designated: did not participate, limited participation and full participation.
A game status report is due by 5 p.m. Friday for Sunday games.
Here is the Bills vs. 49ers injury report for Week 13:
Buffalo Bills injury update for Week 13
Keon Coleman, WR, wrist
Keon Coleman has missed two straight games with an injured wrist.
Coleman hurt his right wrist on a receiving end of a helmet-to-helmet hit by Dolphins safety Jordan Poyer on the Bills’ game-winning drive on Nov. 3 in Week 9. Poyer was flagged for a 15-yard unnecessary roughness penalty on the hit, which jarred the ball loose on a deep pass attempt from Josh Allen. The penalty extended Buffalo’s drive, enabling Tyler Bass’ 61-yard field goal for the 30-27 win.
Coleman held his wrist as he walked to the sideline. He headed to the locker room in the final seconds and was wearing a brace on the wrist after the game.
The Bills elected not to place Coleman on injured reserve, which would have required him to miss a minimum of four games.
Amari Cooper, WR, wrist
Amari Cooper missed two games with a left wrist injury but returned to make two catches for 55 yards in the Week 11 win over the Kansas City Chiefs. Cooper made a one-handed reception for 30 yards using his left hand in the first quarter.
He suffered the injury at Seattle in Week 8, his second game with Buffalo.
Cooper has seven receptions for 124 yards and a touchdowns in three games since being acquired via trade by Buffalo.
Dalton Kincaid, TE, knee
Dalton Kincaid missed the Bills victory over the Kansas City Chiefs in Week 11 with a knee injury.
He left the Bills’ Week 10 win over the Colts in the first quarter, injuring his left knee diving for a ball. He went into the medical tent and locker room and returned to the sideline wearing a brace on his left knee. Kincaid came back for two snaps in the third quarter. He was initially ruled questionable to return but was downgraded to doubtful and did not come back to play.
Spencer Brown, OT, ankle
Spencer Brown did not play in Week 11 after suffering a right ankle in the fourth quarter against the Colts in Week 10.He walked off under his own power, was tended to by medical trainers and returned to the game.
Matt Milano, LB, biceps
Buffalo opened Matt Milano’s practice window from injured reserve on Nov. 11. The Pro Bowl linebacker tore his biceps in training camp and has been on injured reserve all season. The Bills have 21 days from Nov. 11 to place Milano on the active roster or decide if he’ll stay on IR for the rest of the year.
“We’ll see where he’s at and how it goes,” Bills coach Sean McDermott said. “Take it one day and one week at a time.”
Injured reserve
The following Bills players are on injured reserve:
Dawuane Smoot, DE, wristDeWayne Carter, DT, wristTylan Grable, OT, abdomenTravis Clayton, OT, shoulderMatt Milano, LB, bicepsShane Buechele, QB, neckTommy Doyle, OT, kneeBaylon Spector, LB
San Francisco 49ers injury update for Week 13
Brock Purdy, QB, shoulder
Brock Purdy suffered a right shoulder injury in Week 11 and missed San Francisco’s Week 12 loss to Green Bay. He could not indicate a specific play which he hurt the shoulder but he had soreness during and after the game.
Purdy received an MRI on his shoulder Nov. 18 which showed no structural damage, according to 49ers head coach Kyle Shanahan. Shanahan confirmed Purdy underwent a second MRI on Nov. 21.
San Francisco initially didn’t expect him to miss time. Purdy was a limited practice early in the week but did not practice Friday and was ruled out against the Packers.
“This is something that we didn’t think would happen early in the week,” Shanahan said. “We were fully preparing for Brock to go (against Green Bay) and got a little surprised about this yesterday.”
San Francisco has eyed Sunday Night Football against the Bills for Purdy’s return, according to ESPN’s Adam Schefter.
“He did some light throwing today and it went all good,” Shanahan said Monday. “Well see how he feels as the week goes.
Purdy plans to rest Tuesday.
“We rested it throughout the weekend hoping that would help. He threw lighter today to see if that rest helped and it the rest did help him,” Shanahan said. “We’ll see how it feels on Wednesday and take the exact same course throughout the week. Hopefully it responds better this week than it did last week.”
Nick Bosa, DE, hip/obliques
Nick Bosa has been hampered by injuries to both hips and obliques for a month and did not play against Green Bay in Week 12.
The 2022 NFL Defensive Player of the Year exited in the third quarter against the Seattle Seahawks after sacking quarterback Geno Smith in Week 11 and did not return to the game. San Francisco led 10-6 when he left the game but lost 20-17.
Bosa said he was playing through right hip and oblique injuries but was “compensating” and injured his left side.
“Just waiting to see how they respond,” 49ers head coach Kyle Shanahan said of Bosa and offensive tackle Trent Williams. “They didn’t respond great last week, that’s why they weren’t able to go. Nick and Trent are both in the same boat.
“Hopefully it turns a better corner than it did last week.”
Charvarius Ward, CB, personal
Charvarius Ward has missed three consecutive games following the death of his 1-year-old daughter. He returned to practice last week for the first time since late October.
Trent Williams, OT, ankle
Trent Williams missed Week 12 with an ankle injury. He suffered the injury in Week 10 against the Tampa Bay Buccaneers but played through it in a home loss to the Seattle Seahawks in Week 11.
The 11-time Pro Bowl selection was inactive due to the ankle against the Green Bay Packers in Week 12. Williams did not practice leading up to the Packers game and tested the ankle in pregame warmups before sitting out.
Jacob Cowing, WR, concussion
Jacob Cowing sustained a concussion after receiving a knee to the helmet on a punt return against the Seattle Seahawks in Week 11. He went into the blue medical tent, walked to the locker room and was ruled out for the game with a concussion.
He was ruled out for Week 12 against Green Bay.
Cowing, a rookie fourth-round pick, has been the teams primary punt returner with 15 returns for 124 yards (8.3 avg.).
Jordan Elliott, DT, concussion
Jordan Elliott suffered a concussion in the second quarter against Green Bay and was ruled out for the remainder of the game.
San Francisco head coach Kyle Shanahan said Monday that Elliott is in the NFL concussion protocol.
Demetrius Flannigan-Fowles, LB, knee
Demetrius Flannigan-Fowles suffered a knee injury in Week 12 against Green Bay. He was initially ruled questionable to return before being downgraded to out.
Flannigan-Fowles is considered “day-to-day” according to 49ers head coach Kyle Shanahan.
Renardo Green, CB, neck
Renardo Green injured his neck in Week 12 against Green Bay.
Green is considered “day-to-day” according to 49ers head coach Kyle Shanahan.
Aaron Banks, OG, concussion
Aaron Banks suffered a concussion in the Week 12 loss to Green Bay.
San Francisco head coach Kyle Shanahan said Monday that Green is in the NFL concussion protocol.
Dominick Puni, OL, shoulder
Dominick Puni has a shoulder injury and is still being evaluated as the team waits for results of an MRI, San Francisco head coach Kyle Shanahan said Monday.
Deommodore Lenoir, CB, knee
Deommodore Lenoir suffered a knee injury in Week 12 and the team is waiting on results of an MRI, San Francisco head coach Kyle Shanahan said Monday.
Dre Greenlaw, LB, Achilles
San Francisco will open Dre Greenlaw’s 21-day practice window on injured reserve and he will practice Wednesday, according to 49ers head coach Kyle Shanahan.
Greenlaw suffered a torn Achilles in a 25-22 overtime loss to the Kansas City Chiefs in Super Bowl 58. He has been on the reserve/physically unable to perform list all season. Greenlaw had back-to-back seasons with more than 120 total tackles in 2022 and 2023.
Kevin Givens, DT, groin
Kevin Givens is expected to return to practice after missing four games with a groin injury.
Injured reserve
The following 49ers players are on injured reserve:
Brandon Aiyuk, WRTatum Bethune, LBJon Feliciano, OLJavon Hargrave, DLTalanoa Hufanga, SDarrell Luther Jr., CBElijah Mitchell, RBCurtis Robinson, LBAmbry Thomas, CBMitch Wishnowsky, P
Reserve/Physically Unable to Perform
Dre Greenlaw, LBDrake Jackson, DL
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