Buffalo (9-2) brings a six-game winning streak into a matchup with San Francisco (5-6) on Sunday, December 1, 2024 at Highmark Stadium. The Bills are listed as favorites in this one, with the spread sitting at 6 points. The over/under in the contest is set at 44.5 points.
In their last contest, the 49ers lost versus the Green Bay Packers, 38-10.
In that matchup versus the Packers, Niners quarterback Brandon Allen completed 17 of 29 attempts for 199 yards, with one touchdown and one interception.
The Bills won versus the Kansas City Chiefs in their most recent game, 30-21.
49ers vs Bills betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 8:47 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: Buffalo (-6)
Moneyline: Buffalo (-279), San Francisco (+227)
Total: 44.5 points
49ers betting insights
San Francisco is 2-3 overall, with just one win against the spread, in away games.
The 49ers are 4-7-0 against the spread this season.
San Francisco is winless ATS (0-1) as 6-point underdogs or more on the road.
The 49ers have not covered a spread (0-1) when playing as at least 6-point underdogs.
San Francisco has gone over the total in three of five road games this year.
This year, 49ers games have hit the over six times.
49ers leaders
Brock Purdy: 2,613 PASS YDS / 261.3 YPG / 66% / 13 TD / 8 INT / 51 CAR / 267 RUSH YDS / 4 TD
Jordan Mason: 140 CAR / 711 YDS / 64.6 YPG / 3 TD / 11 REC / 91 YDS / 8.3 YPG / 0 TD
George Kittle: 49 REC / 642 YDS / 71.3 YPG / 8 TD
Jauan Jennings: 47 REC / 628 YDS / 69.8 YPG / 4 TD
Deebo Samuel: 34 REC / 511 YDS / 51.1 YPG / 1 TD
49ers vs Bills game info
Date: Sunday, December 1, 2024
Time: 8:20 p.m. ET
City: Orchard Park, New York
Venue: Highmark Stadium
TV Channel: NBC
Live Stream: Fubo (Watch Bills vs 49ers on Fubo)
Live Stream: Watch on Peacock
Watch the San Francisco 49ers all season on Fubo!
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