Buffalo (9-2) brings a six-game winning streak into a matchup with San Francisco (5-6) on Sunday, December 1, 2024 at Highmark Stadium. The Bills are listed as favorites in this one, with the spread sitting at 6 points. The over/under for the contest is 44.5 points.
In their most recent game, the Bills won against the Kansas City Chiefs, 30-21.
The Bills’ Josh Allen went 27-for-40 for 262 yards against the Chiefs, with one TD and one INT.
The 49ers lost to the Green Bay Packers, 38-10, in their last contest.
Bills vs 49ers betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 9:23 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: Buffalo (-6)
Moneyline: Buffalo (-279), San Francisco (+227)
Total: 44.5 points
Bills betting insights
At home this season, Buffalo is 3-2 against the spread and 5-0 overall.
The Bills have put together a record of 7-4-0 against the spread this season.
At home, Buffalo has one win ATS (1-2) as 6-point favorites or more.
In games they have played as 6-point favorites or more, the Bills have an ATS record of 1-2.
Buffalo has hit the over in all five home games this year.
This season, seven Bills games have gone over the point total.
Bills leaders
Allen: 2,543 PASS YDS / 231.2 YPG / 64% / 18 TD / 5 INT / 67 CAR / 316 RUSH YDS / 5 TD
James Cook: 137 CAR / 596 YDS / 59.6 YPG / 10 TD / 25 REC / 182 YDS / 18.2 YPG / 1 TD
Khalil Shakir: 56 REC / 599 YDS / 59.9 YPG / 2 TD
Keon Coleman: 22 REC / 417 YDS / 46.3 YPG / 3 TD
Amari Cooper: 31 REC / 374 YDS / 41.6 YPG / 3 TD
Bills vs 49ers game info
Date: Sunday, December 1, 2024
Time: 8:20 p.m. ET
City: Orchard Park, New York
Venue: Highmark Stadium
TV Channel: NBC
Live Stream: Fubo (Watch Bills vs 49ers on Fubo)
Live Stream: Watch on Peacock
Watch the Buffalo Bills all season on Fubo!
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