By William GreenOctober 25, 2025 Business Spruce Biosciences Earns FDA Breakthrough Therapy Designation for Promising Sanfilippo Syndrome Type B Treatment Spruce Biosciences has received FDA Breakthrough Therapy Designation for Tralesinidase Alfa (TA-ERT), an enzyme replacement therapy targeting Sanfilippo Syndrome Type B (MPS IIIB), advancing treatment prospects for this rare disorder.